Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold
Epothilones are bacterial macrolides with potent microtubule-stabilizing and antiproliferative activity, which have served as successful lead structures for the discovery of several clinical candidates for cancer treatment. Overall, seven epothilone-type agents have been advanced to clinic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2010-02-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/4789 |