Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold

Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold

Epothilones are bacterial macrolides with potent microtubule-stabilizing and antiproliferative activity, which have served as successful lead structures for the discovery of several clinical candidates for cancer treatment. Overall, seven epothilone-type agents have been advanced to clinic...

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Bibliographic Details
Main Authors: Karl-Heinz Altmann, Frédéric Cachoux, Fabian Feyen, Jürg Gertsch, Christian N. Kuzniewski, Markus Wartmann
Format: Article
Language:deu
Published: Swiss Chemical Society 2010-02-01
Series:CHIMIA
Subjects:
Anticancer
Azathilones
Drug discovery
Epothilones
Natural product synthesis
Online Access:https://www.chimia.ch/chimia/article/view/4789

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