Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding

Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding

Abstract Background There is great interest to engineer in vitro models that allow the study of complex biological processes of the microvasculature with high spatiotemporal resolution. Microfluidic systems are currently used to engineer microvasculature in vitro, which consists of perfusable microv...

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Bibliographic Details
Main Authors: Ho-Ying Wan, Jack Chun Hin Chen, Qinru Xiao, Christy Wingtung Wong, Boguang Yang, Benjamin Cao, Rocky S. Tuan, Susan K. Nilsson, Yi-Ping Ho, Michael Raghunath, Roger D. Kamm, Anna Blocki
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-04-01
Series:Biomaterials Research
Subjects:
Microvascular networks
Microfluidic device
Macromolecular crowding
Vessel retraction
Basement membrane
Vascular barrier function
Online Access:https://doi.org/10.1186/s40824-023-00375-w

Internet

https://doi.org/10.1186/s40824-023-00375-w

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