Phenotypic Evaluation of Nucleoside Analogues against <i>Trypanosoma cruzi</i> Infection: In Vitro and In Vivo Approaches

Phenotypic Evaluation of Nucleoside Analogues against <i>Trypanosoma cruzi</i> Infection: In Vitro and In Vivo Approaches

Chagas disease, caused by <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>), is a serious public health problem. Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious efficacy and safety drawbacks. Nucleoside analogues represent a promising al...

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Bibliographic Details
Main Authors: Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girão, Fabian Hulpia, Paula Finamore-Araújo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacílio Moreira, Serge Van Calenbergh, Maria de Nazaré C. Soeiro
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
Chagas disease
<i>Trypanosoma cruzi</i>
experimental chemotherapy
nucleoside derivatives
thymidine transporter
Online Access:https://www.mdpi.com/1420-3049/27/22/8087

Internet

https://www.mdpi.com/1420-3049/27/22/8087

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