Transcription factor family‐specific DNA shape readout revealed by quantitative specificity models

Transcription factor family‐specific DNA shape readout revealed by quantitative specificity models

Abstract Transcription factors (TFs) achieve DNA‐binding specificity through contacts with functional groups of bases (base readout) and readout of structural properties of the double helix (shape readout). Currently, it remains unclear whether DNA shape readout is utilized by only a few selected TF...

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Bibliographic Details
Main Authors: Lin Yang, Yaron Orenstein, Arttu Jolma, Yimeng Yin, Jussi Taipale, Ron Shamir, Remo Rohs
Format: Article
Language:English
Published: Springer Nature 2017-02-01
Series:Molecular Systems Biology
Subjects:
binding specificity
DNA shape
feature selection
quantitative modeling
transcription factor
Online Access:https://doi.org/10.15252/msb.20167238

Internet

https://doi.org/10.15252/msb.20167238

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