Biofilm formation is a risk factor for late and delayed complications of filler injection
IntroductionBiofilm formation is a major cause of delayed-graft complications. Similarly to implants, dermal fillers carry the risk of biofilm formation, which can lead to the development of nodules, chronic inflammatory reactions, abscesses and other complications. In this study, we investigated th...
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| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1297948/full |
| _version_ | 1827387667561578496 |
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| author | You-liang Zhang You-liang Zhang Zhong-sheng Sun Wei-jin Hong Yin Chen Yang-fan Zhou Sheng-kang Luo |
| author_facet | You-liang Zhang You-liang Zhang Zhong-sheng Sun Wei-jin Hong Yin Chen Yang-fan Zhou Sheng-kang Luo |
| author_sort | You-liang Zhang |
| collection | DOAJ |
| description | IntroductionBiofilm formation is a major cause of delayed-graft complications. Similarly to implants, dermal fillers carry the risk of biofilm formation, which can lead to the development of nodules, chronic inflammatory reactions, abscesses and other complications. In this study, we investigated the late or delayed complications associated with biofilm formation on dermal fillers.MethodsIn this retrospective analysis, we analyzed all cases of complications caused by filler injections at a single center between January 2017 and December 2022, the majority of which comprised nodule formation and chronic persistent inflammatory reactions. The risk of biofilm formation with fillers was summarized and analyzed based on the results of bacterial culture and pathological examination.ResultsSixty-one patients were enrolled, including 42 cases of nodule formation, 15 of chronic inflammatory reactions, and 4 of active infection. Bacterial culture of the tissue samples obtained from seven patients after surgical treatment were positive, and comprised four cases of Staphylococcus aureus, one case of Staphylococcus epidermidis, one case of Staphylococcus saprophyticus and one case of Mycobacterium abscessus. The corresponding histopathological results indicated extensive mononuclear lymphocyte infiltration, with a giant cell reaction in the fibrous connective tissue.ConclusionThe results of this study suggest that biofilm formation is a significant risk factor for late and delayed complications following filler injection, and is caused by the contamination of resident bacteria and recessive infection at the injection site. |
| first_indexed | 2024-03-08T16:06:32Z |
| format | Article |
| id | doaj.art-876b601ed9874c1f95c15682828031aa |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T16:06:32Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-876b601ed9874c1f95c15682828031aa2024-01-08T05:42:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-01-011410.3389/fmicb.2023.12979481297948Biofilm formation is a risk factor for late and delayed complications of filler injectionYou-liang Zhang0You-liang Zhang1Zhong-sheng Sun2Wei-jin Hong3Yin Chen4Yang-fan Zhou5Sheng-kang Luo6The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaDepartment of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaDepartment of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaDepartment of Health Management, Guangdong Second Provincial Genera Hospital, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaDepartment of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, ChinaIntroductionBiofilm formation is a major cause of delayed-graft complications. Similarly to implants, dermal fillers carry the risk of biofilm formation, which can lead to the development of nodules, chronic inflammatory reactions, abscesses and other complications. In this study, we investigated the late or delayed complications associated with biofilm formation on dermal fillers.MethodsIn this retrospective analysis, we analyzed all cases of complications caused by filler injections at a single center between January 2017 and December 2022, the majority of which comprised nodule formation and chronic persistent inflammatory reactions. The risk of biofilm formation with fillers was summarized and analyzed based on the results of bacterial culture and pathological examination.ResultsSixty-one patients were enrolled, including 42 cases of nodule formation, 15 of chronic inflammatory reactions, and 4 of active infection. Bacterial culture of the tissue samples obtained from seven patients after surgical treatment were positive, and comprised four cases of Staphylococcus aureus, one case of Staphylococcus epidermidis, one case of Staphylococcus saprophyticus and one case of Mycobacterium abscessus. The corresponding histopathological results indicated extensive mononuclear lymphocyte infiltration, with a giant cell reaction in the fibrous connective tissue.ConclusionThe results of this study suggest that biofilm formation is a significant risk factor for late and delayed complications following filler injection, and is caused by the contamination of resident bacteria and recessive infection at the injection site.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1297948/fullbiofilmsoft tissue fillerhyaluronic acidcomplicationshistopathology |
| spellingShingle | You-liang Zhang You-liang Zhang Zhong-sheng Sun Wei-jin Hong Yin Chen Yang-fan Zhou Sheng-kang Luo Biofilm formation is a risk factor for late and delayed complications of filler injection Frontiers in Microbiology biofilm soft tissue filler hyaluronic acid complications histopathology |
| title | Biofilm formation is a risk factor for late and delayed complications of filler injection |
| title_full | Biofilm formation is a risk factor for late and delayed complications of filler injection |
| title_fullStr | Biofilm formation is a risk factor for late and delayed complications of filler injection |
| title_full_unstemmed | Biofilm formation is a risk factor for late and delayed complications of filler injection |
| title_short | Biofilm formation is a risk factor for late and delayed complications of filler injection |
| title_sort | biofilm formation is a risk factor for late and delayed complications of filler injection |
| topic | biofilm soft tissue filler hyaluronic acid complications histopathology |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1297948/full |
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