Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents

Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents

The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work, two series of compounds based on 8-hydroxyqui...

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书目详细资料
Main Authors: Mahmoud El Safadi, Katie A. Wilson, Indigo J. Strudwicke, Megan L. O’Mara, Mohan Bhadbhade, Tristan Rawling, Andrew M. McDonagh
格式: 文件
语言:English
出版: MDPI AG 2024-09-01
丛编:Molecules
主题:
iron chelator
amphetamine-type chelator
antioxidant
molecular dynamics
human dopamine transporter
在线阅读:https://www.mdpi.com/1420-3049/29/17/4213

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https://www.mdpi.com/1420-3049/29/17/4213

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