A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy

A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy

Abstract Background Renal cell carcinoma (RCC) is a heterogeneous disease comprising histologically defined subtypes. For therapy selection, precise subtype identification and individualized prognosis are mandatory, but currently limited. Our aim was to refine subtyping and outcome prediction across...

Full description

Bibliographic Details
Main Authors: Florian A. Büttner, Stefan Winter, Viktoria Stühler, Steffen Rausch, Jörg Hennenlotter, Susanne Füssel, Stefan Zastrow, Matthias Meinhardt, Marieta Toma, Carmen Jerónimo, Rui Henrique, Vera Miranda-Gonçalves, Nils Kröger, Silvia Ribback, Arndt Hartmann, Abbas Agaimy, Christine Stöhr, Iris Polifka, Falko Fend, Marcus Scharpf, Eva Comperat, Gabriel Wasinger, Holger Moch, Arnulf Stenzl, Marco Gerlinger, Jens Bedke, Matthias Schwab, Elke Schaeffeler
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Medicine
Subjects:
Renal cell carcinoma
Cancer-specific survival
RCC subtypes
Gene expression deconvolution
Immunotherapy
Online Access:https://doi.org/10.1186/s13073-022-01105-y

Internet

https://doi.org/10.1186/s13073-022-01105-y

Similar Items