Evaluation of trabecular meshwork-specific promoters in vitro and in vivo using scAAV2 vectors expressing C3 transferase

Evaluation of trabecular meshwork-specific promoters in vitro and in vivo using scAAV2 vectors expressing C3 transferase

AIM: To evaluate the potential of two trabecular meshwork (TM)-specific promoters, Chitinase 3-like 1 (Ch3L1) and matrix gla protein (MGP), for improving specificity and safety in glaucoma gene therapy based on self-complementary AAV2 (scAAV2) vector technologies. METHODS: An scAAV2 vector with C3 t...

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Bibliographic Details
Main Authors: Jun-Kai Tan, Ying Xiao, Guo Liu, Long-Xiang Huang, Wen-Hao Ma, Yan Xia, Xi-Zhen Wang, Xian-Jun Zhu, Su-Ping Cai, Xiao-Bing Wu, Yun Wang, Xu-Yang Liu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2023-08-01
Series:International Journal of Ophthalmology
Subjects:
self-complementary aav2
chitinase 3-like 1
matrix gla protein
trabecular meshwork
c3 transferase
Online Access:http://ies.ijo.cn/en_publish/2023/8/20230803.pdf

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http://ies.ijo.cn/en_publish/2023/8/20230803.pdf

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