Focus on <i>RAS</i> Codon 61 Mutations in Metastatic Colorectal Cancer: A Retrospective Analysis

Focus on <i>RAS</i> Codon 61 Mutations in Metastatic Colorectal Cancer: A Retrospective Analysis

<i>RAS</i> mutations involving codon 61 are rare in metastatic colorectal cancer (mCRC), accounting for only 1–4%, but they have recently been identified with high frequency in the circulating tumor DNA (ctDNA) of patients with secondary resistance to anti-EGFRs. This retrospective monoc...

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Bibliographic Details
Main Authors: Francesco Schietroma, Annunziato Anghelone, Giustina Valente, Viria Beccia, Giulia Caira, Alexia Spring, Giovanni Trovato, Armando Di Bello, Anna Ceccarelli, Laura Chiofalo, Serena Perazzo, Maria Bensi, Angelo Minucci, Andrea Urbani, Luigi Maria Larocca, Michele Basso, Carmelo Pozzo, Lisa Salvatore, Maria Alessandra Calegari, Giampaolo Tortora
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
colorectal adenocarcinoma
RAS
metastatic colorectal cancer
RAS signaling
Codon 61
MAPK pathway
Online Access:https://www.mdpi.com/2072-6694/16/5/988

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https://www.mdpi.com/2072-6694/16/5/988

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