Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.

Bibliographic Details
Main Authors: Yeonkyoung Park, Joori Park, Hyun Jung Hwang, Byungju Kim, Kwon Jeong, Jeeyoon Chang, Jong-Bong Lee, Yoon Ki Kim
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16939-6

Internet

https://doi.org/10.1038/s41467-020-16939-6

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