Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling
Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifesp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00220/full |
| _version_ | 1818254171777794048 |
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| author | Jessika Cristina Bridi Jessika Cristina Bridi Alexandre Guimarães de Almeida Barros Letícia Reis Sampaio Júlia Castro Damásio Ferreira Félix Alexandre Antunes Soares Marco Aurélio eRomano-Silva |
| author_facet | Jessika Cristina Bridi Jessika Cristina Bridi Alexandre Guimarães de Almeida Barros Letícia Reis Sampaio Júlia Castro Damásio Ferreira Félix Alexandre Antunes Soares Marco Aurélio eRomano-Silva |
| author_sort | Jessika Cristina Bridi |
| collection | DOAJ |
| description | Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging. |
| first_indexed | 2024-12-12T16:51:44Z |
| format | Article |
| id | doaj.art-877754585a02456fb73725b2f2632881 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T16:51:44Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-877754585a02456fb73725b2f26328812022-12-22T00:18:21ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-12-01710.3389/fnagi.2015.00220165771Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signalingJessika Cristina Bridi0Jessika Cristina Bridi1Alexandre Guimarães de Almeida Barros2Letícia Reis Sampaio3Júlia Castro Damásio Ferreira4Félix Alexandre Antunes Soares5Marco Aurélio eRomano-Silva6Faculdade de Medicina, Universidade Federal de Minas GeraisInstitute of Psychiatry, Psychology and Neuroscience, King's College London Faculdade de Medicina, Universidade Federal de Minas GeraisFaculdade de Medicina, Universidade Federal de Minas GeraisFaculdade de Medicina, Universidade Federal de Minas GeraisCentro de Ciências Naturais e Exatas, Universidade Federal de Santa MariaFaculdade de Medicina, Universidade Federal de Minas GeraisCaffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00220/fullAdenosineCaenorhabditis elegansCaffeineLifespanInsulin/IGF-1 pathway |
| spellingShingle | Jessika Cristina Bridi Jessika Cristina Bridi Alexandre Guimarães de Almeida Barros Letícia Reis Sampaio Júlia Castro Damásio Ferreira Félix Alexandre Antunes Soares Marco Aurélio eRomano-Silva Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling Frontiers in Aging Neuroscience Adenosine Caenorhabditis elegans Caffeine Lifespan Insulin/IGF-1 pathway |
| title | Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling |
| title_full | Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling |
| title_fullStr | Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling |
| title_full_unstemmed | Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling |
| title_short | Lifespan extension induced by caffeine in Caenorhabditis elegans is partially dependent on adenosine signaling |
| title_sort | lifespan extension induced by caffeine in caenorhabditis elegans is partially dependent on adenosine signaling |
| topic | Adenosine Caenorhabditis elegans Caffeine Lifespan Insulin/IGF-1 pathway |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00220/full |
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