The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer

The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, NKG2D deficiency increases susceptibility to some types of cancer, implicating this syste...

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Bibliographic Details
Main Authors: Ge Tan, Katelyn M. Spillane, John Maher
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/12/8/1079