Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects

Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects

Depression associated with poor general medical condition, such as post-stroke (PSD) or post-myocardial infarction (PMID) depression, is characterized by resistance to classical antidepressants. Special treatment strategies should thus be developed for these conditions. Our study aims to investigate...

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Bibliographic Details
Main Authors: Alexey Sarapultsev, Pavel Vassiliev, Daniil Grinchii, Alexander Kiss, Mojmir Mach, Jana Osacka, Alexandra Balloova, Ruslan Paliokha, Andrey Kochetkov, Larisa Sidorova, Petr Sarapultsev, Oleg Chupakhin, Maxim Rantsev, Alexander Spasov, Eliyahu Dremencov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
treatment-resistant depression
depression due to general medical condition
post-stroke depression
post-myocardial infarction (MI) depression
thiadizines
serotonin transporter (SERT)
Online Access:https://www.mdpi.com/1422-0067/22/24/13626

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https://www.mdpi.com/1422-0067/22/24/13626

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