NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis

NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis

Nuclear receptor subfamily 4 group A1 (NR4A1) is an orphan nuclear receptor, which is expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multiple sclerosis. Knockout of the Nr4a1 gene in mice can aggravate the symptoms of...

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Bibliographic Details
Main Authors: Hai-Zhen Yu, Bing-Qing Zhu, Lin Zhu, Shuo Li, Li-Mei Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
cytosporone b (csn-b); experimental autoimmune encephalomyelitis; macrophages; microglia; multiple sclerosis; nr4a1 agonist; nr4a1; th1; th17; treatment
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2765;epage=2770;aulast=Yu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2765;epage=2770;aulast=Yu

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