High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli

Adherent-invasive E. coli (AIEC) are frequently isolated from Crohn’s disease (CD) patients. Here, Elhenawy et al. conduct a genome-wide screen to identify AIEC genes required for in vivo intestinal colonization, and show that a type IV secretion system contributes to AIEC persistence in the gut and...

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Bibliographic Details
Main Authors: Wael Elhenawy, Sarah Hordienko, Steven Gould, Alexander M. Oberc, Caressa N. Tsai, Troy P. Hubbard, Matthew K. Waldor, Brian K. Coombes
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22306-w

Internet

https://doi.org/10.1038/s41467-021-22306-w

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