Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis

The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are n...

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Bibliographic Details
Main Authors: Rachitha Singhabahu, Sujani M. Kodagoda Gamage, Vinod Gopalan
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cancer Pathogenesis and Therapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2949713223000216