A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib

A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib

Background Various techniques have been employed to detect BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia who are resistant to imatinib. This has led to different reported frequencies of mutations and the finding of a heterogeneous pattern of individual mutations.Design an...

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Bibliographic Details
Main Authors: Thomas Ernst, Franz X. Gruber, Oliver Pelz-Ackermann, Jacqueline Maier, Markus Pfirrmann, Martin C. Müller, Ingvild Mikkola, Kimmo Porkka, Dietger Niederwieser, Andreas Hochhaus, Thoralf Lange
Format: Article
Language:English
Published: Ferrata Storti Foundation 2009-09-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/5344

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https://haematologica.org/article/view/5344

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