Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

<p>Abstract</p> <p>Background</p> <p>Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO). However, AQP4-IgG are absent in 5-40% of all NMO patients and the target of...

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Main Authors: Mader Simone, Gredler Viktoria, Schanda Kathrin, Rostasy Kevin, Dujmovic Irena, Pfaller Kristian, Lutterotti Andreas, Jarius Sven, Di Pauli Franziska, Kuenz Bettina, Ehling Rainer, Hegen Harald, Deisenhammer Florian, Aboul-Enein Fahmy, Storch Maria K, Koson Peter, Drulovic Jelena, Kristoferitsch Wolfgang, Berger Thomas, Reindl Markus
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Journal of Neuroinflammation
Subjects:
Neuromyelitis optica
autoantibodies
myelin oligodendrocyte glycoprotein
aquaporin-4
complement mediated cytotoxicity
biomarker
Online Access:http://www.jneuroinflammation.com/content/8/1/184

Internet

http://www.jneuroinflammation.com/content/8/1/184

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