Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.

Bibliographic Details
Main Authors: Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr, Manfred Lehner
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17970-3

Internet

https://doi.org/10.1038/s41467-020-17970-3

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