Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17970-3 |
| _version_ | 1818842284071845888 |
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| author | Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner |
| author_facet | Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner |
| author_sort | Benjamin Salzer |
| collection | DOAJ |
| description | The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions. |
| first_indexed | 2024-12-19T04:39:31Z |
| format | Article |
| id | doaj.art-8783689044924d8ba5fdd958f3eeabd4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:39:31Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8783689044924d8ba5fdd958f3eeabd42022-12-21T20:35:39ZengNature PortfolioNature Communications2041-17232020-08-0111111610.1038/s41467-020-17970-3Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR functionBenjamin Salzer0Christina M. Schueller1Charlotte U. Zajc2Timo Peters3Michael A. Schoeber4Boris Kovacic5Michelle C. Buri6Elisabeth Lobner7Omer Dushek8Johannes B. Huppa9Christian Obinger10Eva M. Putz11Wolfgang Holter12Michael W. Traxlmayr13Manfred Lehner14St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Medical University of ViennaSt. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Department of Biotechnology, University of Natural Resources and Life SciencesSir William Dunn School of Pathology, University of OxfordCenter for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Medical University of ViennaDepartment of Chemistry, Institute of Biochemistry, University of Natural Resources and Life SciencesSt. Anna Children’s Cancer Research Institute (CCRI)St. Anna Children’s Cancer Research Institute (CCRI)Christian Doppler Laboratory for Next Generation CAR T CellsSt. Anna Children’s Cancer Research Institute (CCRI)The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.https://doi.org/10.1038/s41467-020-17970-3 |
| spellingShingle | Benjamin Salzer Christina M. Schueller Charlotte U. Zajc Timo Peters Michael A. Schoeber Boris Kovacic Michelle C. Buri Elisabeth Lobner Omer Dushek Johannes B. Huppa Christian Obinger Eva M. Putz Wolfgang Holter Michael W. Traxlmayr Manfred Lehner Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function Nature Communications |
| title | Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function |
| title_full | Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function |
| title_fullStr | Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function |
| title_full_unstemmed | Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function |
| title_short | Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function |
| title_sort | engineering avidcars for combinatorial antigen recognition and reversible control of car function |
| url | https://doi.org/10.1038/s41467-020-17970-3 |
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