The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab

Abstract Dismal prognosis of glioblastoma (GBM) prompts for the identification of response predictors and therapeutic resistance mechanisms of current therapies. The authors investigated the impact of c-Met, HGF, VEGFR2 expression and microvessel density (MVD) in GBM patients submitted to second-lin...

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Bibliographic Details
Main Authors: Bruno Carvalho, José Manuel Lopes, Roberto Silva, Joana Peixoto, Dina Leitão, Paula Soares, Ana Catarina Fernandes, Paulo Linhares, Rui Vaz, Jorge Lima
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85385-1