G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling

G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling

G protein-coupled receptors (GPCRs) are a large membrane protein family found in higher organisms, including the human body. GPCRs mediate cellular responses to diverse extracellular stimuli and thus control key physiological functions, which makes them important targets for drug design. Signaling b...

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Bibliographic Details
Main Authors: Haoyi Ge, Huixia Wang, Benxun Pan, Dandan Feng, Canyong Guo, Lingyun Yang, Dongsheng Liu, Kurt Wüthrich
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
G protein-coupled receptors
<sup>19</sup>F-NMR
membrane mimetics
stable-isotope labeling
in-membrane chemical modification
amino-acid-specific NMR labeling
Online Access:https://www.mdpi.com/1420-3049/27/9/2658

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https://www.mdpi.com/1420-3049/27/9/2658

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