Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations

Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations

Summary: 3′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic gene dysregulation. To determine the significance of 3′ UTR mutations in disease, we identify 3′ UTR somatic variants across 185 advanced prostate tumors, discovering 14,497 sing...

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Bibliographic Details
Main Authors: Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Pushpa Itagi, Lukas Corey, Dave Young, Bethany L. Stackhouse, Lori Kollath, Qian V. Wu, Eva Corey, Lawrence D. True, Gavin Ha, Patrick J. Paddison, Andrew C. Hsieh
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008513

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723008513

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