HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to quantify capmatinib in plasma for the first t...

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Bibliographic Details
Main Authors: Aref Zayed, Sana’a A. Jaber, Jomana Al Hroot, Sahar Hawamdeh, Nehad M. Ayoub, Nidal A. Qinna
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
capmatinib
HPLC
pharmacokinetics
fluorescence
rat plasma
microsomes
Online Access:https://www.mdpi.com/1420-3049/27/23/8582

Internet

https://www.mdpi.com/1420-3049/27/23/8582

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