A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis
Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-04-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22004157 |
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| author | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang |
| author_facet | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang |
| author_sort | Yibo Ying |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing it to match the physical properties of the spinal cord; additionally, this hydrogel scavenges ROS well, allowing it to inhibit the lipid peroxidation caused by ferroptosis. According to the in vivo studies, the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism. In addition, dental pulp stem cells (DPSCs) were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses. It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI. |
| first_indexed | 2024-04-10T20:56:50Z |
| format | Article |
| id | doaj.art-8790e167cda24d26b737d1537b60a9b1 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:34:37Z |
| publishDate | 2023-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-8790e167cda24d26b737d1537b60a9b12024-04-16T17:41:26ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-04-0122274290A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosisYibo Ying0Zhiyang Huang1Yurong Tu2Qiuji Wu3Zhaoyu Li4Yifan Zhang5Huilei Yu6Annian Zeng7Hanzhi Huang8Jiahui Ye9Weiyang Ying10Min Chen11Zhiyi Feng12Ziyue Xiang13Qingsong Ye14Sipin Zhu15Zhouguang Wang16School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Overseas Education College, Jimei University, Xiamen, Fujian, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, 460030, Hubei, China; Massachusetts General Hospital, Harvard University, Boston, 02114, USA; Corresponding author. Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, 460030, Hubei, China.School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding author. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding author. School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing it to match the physical properties of the spinal cord; additionally, this hydrogel scavenges ROS well, allowing it to inhibit the lipid peroxidation caused by ferroptosis. According to the in vivo studies, the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism. In addition, dental pulp stem cells (DPSCs) were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses. It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI.http://www.sciencedirect.com/science/article/pii/S2452199X22004157Shear-thinning hydrogelDental pulp stem cellsFerroptosisROS-ScavengingSynaptic regulation |
| spellingShingle | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis Bioactive Materials Shear-thinning hydrogel Dental pulp stem cells Ferroptosis ROS-Scavenging Synaptic regulation |
| title | A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| title_full | A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| title_fullStr | A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| title_full_unstemmed | A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| title_short | A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| title_sort | shear thinning ros scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis |
| topic | Shear-thinning hydrogel Dental pulp stem cells Ferroptosis ROS-Scavenging Synaptic regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22004157 |
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