Optimizing information in Next-Generation-Sequencing (NGS) reads for improving de novo genome assembly.

Optimizing information in Next-Generation-Sequencing (NGS) reads for improving de novo genome assembly.

Next-Generation-Sequencing is advantageous because of its much higher data throughput and much lower cost compared with the traditional Sanger method. However, NGS reads are shorter than Sanger reads, making de novo genome assembly very challenging. Because genome assembly is essential for all downs...

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Bibliographic Details
Main Authors: Tsunglin Liu, Cheng-Hung Tsai, Wen-Bin Lee, Jung-Hsien Chiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726674?pdf=render

Internet

http://europepmc.org/articles/PMC3726674?pdf=render

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