Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway

Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway

Excessive reactive oxygen species (ROS) production leads to oxidative stress in cells, impairing the function of mitochondria and finally inducing cell apoptosis. Considering the essential role of oxidative stress in the pathogenesis of various neurodegenerative diseases and psychiatric disorders, t...

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Bibliographic Details
Main Authors: Liang Xiong, Hongshan Wu, Ting Zhong, Fang Luo, Qing Li, Mei Li, Yanhua Fan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
1,4-disubstituted piperazine-2,5-diones
oxidative stress
cell apoptosis
cell survival
IL-6/Nrf2 positive-feedback loop
Online Access:https://www.mdpi.com/2076-3921/11/10/2014

Internet

https://www.mdpi.com/2076-3921/11/10/2014

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