A systematic review of simulation studies which compare existing statistical methods to account for non-compliance in randomised controlled trials

A systematic review of simulation studies which compare existing statistical methods to account for non-compliance in randomised controlled trials

Abstract Introduction Non-compliance is a common challenge for researchers and may reduce the power of an intention-to-treat analysis. Whilst a per protocol approach attempts to deal with this issue, it can result in biased estimates. Several methods to resolve this issue have been identified in pre...

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Bibliographic Details
Main Authors: Lucy Abell, Francesca Maher, Angus C Jennings, Laura J Gray
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Medical Research Methodology
Subjects:
Non-compliance
Simulation studies
Statistical methods
Randomised controlled trials
Online Access:https://doi.org/10.1186/s12874-023-02126-w

Internet

https://doi.org/10.1186/s12874-023-02126-w

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