Apolipoprotein E Genotype e2: Neuroprotection and Its Limits

In this review, we comprehensively, qualitatively, and critically synthesized several features of APOE-e2, a known APOE protective variant, including its associations with longevity, cognition, and neuroimaging, and neuropathology, all in humans. If e2’s protective effects—and their limits—could be...

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Bibliographic Details
Main Authors: Hyun Kim, Davangere P. Devanand, Scott Carlson, Terry E. Goldberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.919712/full