Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice

Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice

Nuciferine (Nuci), the main aporphine alkaloid component in lotus leaf, was reported to reduce lipid accumulation in vitro. Herein we investigated whether Nuci prevents obesity in high fat diet (HFD)-fed mice and the underlying mechanism in liver/HepG2 hepatocytes and epididymal white adipose tissue...

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Bibliographic Details
Main Authors: Hanyuan Xu, Xiaorui Lyu, Xiaonan Guo, Hongbo Yang, Lian Duan, Huijuan Zhu, Hui Pan, Fengying Gong, Linjie Wang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
Nuciferine (Nuci)
AMP-activated protein kinase (AMPK)
fatty acid synthase (FAS)
hormone sensitive lipase (HSL)
obesity
hepatic steatosis
Online Access:https://www.mdpi.com/2072-6643/14/9/1898

Internet

https://www.mdpi.com/2072-6643/14/9/1898

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