RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling

RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling

Objectives: To investigate the potential role of Ribosomal protein L35 (RPL35) in regulating chondrocyte catabolic metabolism and to examine whether osteoarthritis (OA) progression can be delayed by overexpressing RPL35 in a mouse compression loading model. Methods: RNA sequencing analysis was perfo...

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Bibliographic Details
Main Authors: Jinjian Zhu, Liangliang Liu, Rengui Lin, Xiongtian Guo, Jianbin Yin, Haoyu Xie, Yuheng Lu, Zhicheng Zhang, Hongbo Zhang, Zihao Yao, Haiyan Zhang, Xiangjiang Wang, Chun Zeng, Daozhang Cai
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Chondrocyte
Hedgehog pathway
Osteoarthritis
Ribosomal protein L35
Senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24000056

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http://www.sciencedirect.com/science/article/pii/S2214031X24000056

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