MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

Abstract Background Metabolic reprogramming is a hallmark of cancer, alteration of nucleotide metabolism of hepatocellular carcinoma (HCC) is not well-understood. MYBL2 regulates cell cycle progression and hepatocarcinogenesis, its role in metabolic regulation remains elusive. Patients and methods C...

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Bibliographic Details
Main Authors: Jun-Zhang Zhao, Wei Wang, Tao Liu, Lei Zhang, De-Zheng Lin, Jia-Yin Yao, Xiang Peng, Gang Jin, Tian-Tian Ma, Jin-Bo Gao, Fang Huang, Jun Nie, Qing Lv
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
MYBL2
IMPDH1
Purine synthesis
HCC
Online Access:https://doi.org/10.1186/s12885-022-10354-4

Internet

https://doi.org/10.1186/s12885-022-10354-4

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