TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3
Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes fr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08584-5 |
| _version_ | 1818842136264572928 |
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| author | John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang |
| author_facet | John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang |
| author_sort | John P. Dowling |
| collection | DOAJ |
| description | Programmed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes from TNF-induced apoptosis. |
| first_indexed | 2024-12-19T04:37:10Z |
| format | Article |
| id | doaj.art-87a04eb49a6d4286879173b72990596b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:37:10Z |
| publishDate | 2019-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-87a04eb49a6d4286879173b72990596b2022-12-21T20:35:44ZengNature PortfolioNature Communications2041-17232019-02-0110111010.1038/s41467-019-08584-5TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3John P. Dowling0Mohamed Alsabbagh1Christina Del Casale2Zheng-Gang Liu3Jianke Zhang4Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityCenter for Cancer Research, National Cancer InstituteDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityProgrammed cell death regulates early development but how various factors (for example, TRADD, FADD and RIPKs) regulate this is unclear. Here, the authors show that a single allele of Tradd is essential for survival, when both Ripk3 and Ripk1 are knocked out in mice, and RIPK1 protects thymocytes from TNF-induced apoptosis.https://doi.org/10.1038/s41467-019-08584-5 |
| spellingShingle | John P. Dowling Mohamed Alsabbagh Christina Del Casale Zheng-Gang Liu Jianke Zhang TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 Nature Communications |
| title | TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 |
| title_full | TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 |
| title_fullStr | TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 |
| title_full_unstemmed | TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 |
| title_short | TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3 |
| title_sort | tradd regulates perinatal development and adulthood survival in mice lacking ripk1 and ripk3 |
| url | https://doi.org/10.1038/s41467-019-08584-5 |
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