Long-Term Exercise Reduces Formation of Tubular Aggregates and Promotes Maintenance of Ca2+ Entry Units in Aged Muscle

Long-Term Exercise Reduces Formation of Tubular Aggregates and Promotes Maintenance of Ca2+ Entry Units in Aged Muscle

Tubular aggregates (TAs) in skeletal muscle fibers are unusual accumulation of sarcoplasmic reticulum (SR) tubes that are found in different disorders including TA myopathy (TAM). TAM is a muscular disease characterized by muscle pain, cramping, and weakness that has been recently linked to mutation...

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Bibliographic Details
Main Authors: Simona Boncompagni, Claudia Pecorai, Antonio Michelucci, Laura Pietrangelo, Feliciano Protasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
sarcoplasmic reticulum
transverse tubule
excitation-contraction coupling
electron microscopy
store opereted calcium entry
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.601057/full

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https://www.frontiersin.org/articles/10.3389/fphys.2020.601057/full

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