Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Chagas disease, caused by the parasite <i>Trypanosoma cruzi</i> (<i>T. cruzi</i>), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas disease cardiom...

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Bibliographic Details
Main Authors: Carolina Kymie Vasques Nonaka, Gabriela Louise Sampaio, Luciana de Aragão França, Bruno Raphael Cavalcante, Katia Nunes Silva, Ricardo Khouri, Felipe Guimarães Torres, Cassio Santana Meira, Emanuelle de Souza Santos, Carolina Thé Macedo, Bruno Diaz Paredes, Vinicius Pinto Costa Rocha, Silvia Regina Rogatto, Ricardo Ribeiro dos Santos, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
microRNA
therapeutic target
Chagas disease
cardiomyopathy
fibrosis
miR-21
Online Access:https://www.mdpi.com/1422-0067/22/7/3307

Internet

https://www.mdpi.com/1422-0067/22/7/3307

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