Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Stress is well known to contribute to the development of both neurological and psychiatric diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in modulating immunological responses has been widely suggested, and this protein possesses both neurotoxic and neurop...

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Bibliographic Details
Main Authors: Na Duan, Yanpeng Zhang, Shuwen Tan, Jianyu Sun, Mao Ye, Hui Gao, Kairui Pu, Meiyan Wu, Qiang Wang, Qian Zhai
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neurobiology of Disease
Subjects:
Microglia
Phagocytosis
Interferon
Neuroinflammation
Chronic stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001310

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http://www.sciencedirect.com/science/article/pii/S0969996122001310

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