Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2

Summary: Intranasal infection of k18-hACE2 mice with SARS-CoV-2 recapitulates the clinical characteristics present in severe COVID-19. Here, we present a protocol for intranasal administration of SARS-CoV-2 to k18-hACE2 mice and their subsequent daily monitoring. We describe steps for intranasal ino...

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Bibliographic Details
Main Authors: Joana Couto, Rute Gonçalves, Sofia Lamas, Margarida Saraiva
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166723002708