NAD<sup>+</sup> Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents

NAD<sup>+</sup> Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents

Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD<sup>+</sup>). NAD<sup>+</sup> is an essen...

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Bibliographic Details
Main Authors: Joanna Ruszkiewicz, Ylea Papatheodorou, Nathalie Jäck, Jasmin Melzig, Franziska Eble, Annika Pirker, Marius Thomann, Andreas Haberer, Simone Rothmiller, Alexander Bürkle, Aswin Mangerich
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
nicotinamide adenine dinucleotide
NAD booster
mustard agents
nicotinamide riboside
DNA damage
sulfur mustard
Online Access:https://www.mdpi.com/2073-4409/12/19/2396

Internet

https://www.mdpi.com/2073-4409/12/19/2396

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