Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights

Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights

BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. Individuals with mutations in the BRCA1 and BRCA2 (BRCA1/2) genes have a significantly higher risk of developing vario...

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Bibliographic Details
Main Authors: Ashwin Ragupathi, Manrose Singh, Alexis M. Perez, Dong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
BRCA1 and BRCA2
PARP1
PARP inhibitors
synthetic lethality
breast cancer
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1133472/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1133472/full

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