Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia
The maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose 4 pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregn...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcvm.2015.00020/full |
| _version_ | 1811298800110665728 |
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| author | Kelsey R Bounds M. Karen Newell-Rogers Brett M Mitchell |
| author_facet | Kelsey R Bounds M. Karen Newell-Rogers Brett M Mitchell |
| author_sort | Kelsey R Bounds |
| collection | DOAJ |
| description | The maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose 4 pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregnancy leads to an excessive innate immune response resulting in widespread inflammation, placental and renal dysfunction, vasoconstriction, and PE. Placental dysfunction due to shallow trophoblast invasion, inadequate spiral artery remodeling, and/or low placental perfusion initiates an innate immune response leading to excessive inflammation, endothelial and renal dysfunction, and PE. A heightened innate immune system due to pre-existing or acquired infections plus the presence of a paternally-derived placenta and semi-allogeneic fetus cause an excessive innate immune response which manifests as PE. Lastly, an abnormal and excessive maternal immune response to pregnancy leads to widespread inflammation, organ dysfunction, and PE. We discuss the potential role of innate immunity in each of these scenarios, as well as the overlap, and how targeting the innate immune system might lead to therapies for the treatment of PE. |
| first_indexed | 2024-04-13T06:25:38Z |
| format | Article |
| id | doaj.art-87b13e02a78d4023b66da1ff14365a59 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T06:25:38Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-87b13e02a78d4023b66da1ff14365a592022-12-22T02:58:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2015-04-01210.3389/fcvm.2015.00020138641Four Pathways Involving Innate Immunity in the Pathogenesis of PreeclampsiaKelsey R Bounds0M. Karen Newell-Rogers1Brett M Mitchell2Texas A&M Health Science CenterTexas A&M Health Science CenterTexas A&M Health Science CenterThe maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose 4 pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregnancy leads to an excessive innate immune response resulting in widespread inflammation, placental and renal dysfunction, vasoconstriction, and PE. Placental dysfunction due to shallow trophoblast invasion, inadequate spiral artery remodeling, and/or low placental perfusion initiates an innate immune response leading to excessive inflammation, endothelial and renal dysfunction, and PE. A heightened innate immune system due to pre-existing or acquired infections plus the presence of a paternally-derived placenta and semi-allogeneic fetus cause an excessive innate immune response which manifests as PE. Lastly, an abnormal and excessive maternal immune response to pregnancy leads to widespread inflammation, organ dysfunction, and PE. We discuss the potential role of innate immunity in each of these scenarios, as well as the overlap, and how targeting the innate immune system might lead to therapies for the treatment of PE.http://journal.frontiersin.org/Journal/10.3389/fcvm.2015.00020/fullinnate immunityendothelial dysfunctionimmune cellsPreeclampsiaPlacental dysfunction |
| spellingShingle | Kelsey R Bounds M. Karen Newell-Rogers Brett M Mitchell Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia Frontiers in Cardiovascular Medicine innate immunity endothelial dysfunction immune cells Preeclampsia Placental dysfunction |
| title | Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |
| title_full | Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |
| title_fullStr | Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |
| title_full_unstemmed | Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |
| title_short | Four Pathways Involving Innate Immunity in the Pathogenesis of Preeclampsia |
| title_sort | four pathways involving innate immunity in the pathogenesis of preeclampsia |
| topic | innate immunity endothelial dysfunction immune cells Preeclampsia Placental dysfunction |
| url | http://journal.frontiersin.org/Journal/10.3389/fcvm.2015.00020/full |
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