Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system

Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system

Myosin heavy chain 7 (MYH7) encodes the human heart myosin heavy chain subunit, which plays an important role in myocardial contraction. MYH7 is the main pathogenic gene that causes Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM). In this experiment, a MYH7 homozygous knockout hum...

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Bibliographic Details
Main Authors: Tianwei Guo, Youxu Jiang, Yuanxiu Song, Shuhong Ma, Yun Chang, Siyao Zhang, Hongyue Wang, Tao Dong, Hongfeng Jiang, Wenjing Lu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350612100413X

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http://www.sciencedirect.com/science/article/pii/S187350612100413X

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