Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice

Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice

Context Fibraurea recisa Pierre. (Menispermaceae) (FR) is a traditional Chinese medicine known as “Huangteng.” The total alkaloids of FR (AFR) are the main active ingredients. However, the pharmacological effects of AFR in the treatment of depression have not been reported.Objectives This study inve...

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Bibliographic Details
Main Authors: Zhongmei He, He Yu, Hong Wu, Lili Su, Kun Shi, Yan Zhao, Ying Zong, Weijia Chen, Rui Du
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
CUMS model
network pharmacology
BDNF-MEK/ERK signalling pathway
NLRP3/caspase-1 signalling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2099429

Internet

https://www.tandfonline.com/doi/10.1080/13880209.2022.2099429

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