Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway

Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway

Abstract Background Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineage differentiation, immunosuppressive, and anti-inflammatory potential w...

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Main Authors: Jing-Yuan Li, Kang-Kang Ren, Wen-Jie Zhang, Ling Xiao, Han-You Wu, Qian-Yu Liu, Ting Ding, Xiang-Cheng Zhang, Wen-Jia Nie, Yu Ke, Ke-Yu Deng, Quan-Wen Liu, Hong-Bo Xin
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Human amniotic membrane mesenchymal stem cells
Conditioned medium
Wound healing
PI3K/AKT signaling
Antibody array
Online Access:http://link.springer.com/article/10.1186/s13287-019-1366-y

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http://link.springer.com/article/10.1186/s13287-019-1366-y

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