Genetic Load of Alternations of Transcription Factor Genes in Non-Syndromic Deafness and the Associated Clinical Phenotypes: Experience from Two Tertiary Referral Centers

Genetic Load of Alternations of Transcription Factor Genes in Non-Syndromic Deafness and the Associated Clinical Phenotypes: Experience from Two Tertiary Referral Centers

Sensorineural hearing loss is one of the most common inherited sensory disorders. Functional classifications of deafness genes have shed light on genotype- and mechanism-based pharmacological approaches and on gene therapy strategies. In this study, we characterized the clinical phenotypes and genot...

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Bibliographic Details
Main Authors: Hyung Dong Jo, Jin Hee Han, So Min Lee, Dong Hwa Choi, Sang-Yeon Lee, Byung Yoon Choi
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
transcription factor variants (TF)
non-syndromic hearing loss
<i>POU3F4</i>
<i>POU4F3</i>
<i>LMX1A</i>
<i>EYA4</i>
Online Access:https://www.mdpi.com/2227-9059/10/9/2125

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https://www.mdpi.com/2227-9059/10/9/2125

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