Failure of ALL recognition by CAR T cells: a review of CD 19-negative relapses after anti-CD 19 CAR-T treatment in B-ALL

Failure of ALL recognition by CAR T cells: a review of CD 19-negative relapses after anti-CD 19 CAR-T treatment in B-ALL

The use of chimeric antigen receptor (CAR) T lymphocytes in the treatment of refractory or relapsed (R/R) B cell acute lymphoblastic leukemia (B-ALL) has meant a radical change in the prognosis of these patients, whose chances of survival with conventional treatment are very low. The current probabi...

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Bibliographic Details
Main Authors: Clara Aparicio-Pérez, MDolores Carmona, Karim Benabdellah, Concha Herrera
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
CART cells
B-ALL
CD-19-negative relapse
leukemia evasion
overcome strategies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165870/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165870/full

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