Impact of G-Quadruplex Structures on Methylation of Model Substrates by DNA Methyltransferase Dnmt3a

Impact of G-Quadruplex Structures on Methylation of Model Substrates by DNA Methyltransferase Dnmt3a

In mammals, de novo methylation of cytosines in DNA CpG sites is performed by DNA methyltransferase Dnmt3a. Changes in the methylation status of CpG islands are critical for gene regulation and for the progression of some cancers. Recently, the potential involvement of DNA G-quadruplexes (G4s) in me...

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Bibliographic Details
Main Authors: Andrei G. Loiko, Alexander V. Sergeev, Adelya I. Genatullina, Mayya V. Monakhova, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
Dnmt3a
DNA methylation
protein–DNA binding
Online Access:https://www.mdpi.com/1422-0067/23/18/10226

Internet

https://www.mdpi.com/1422-0067/23/18/10226

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