HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling

HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling

Summary: Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in human keratinocytes through the epidermal type I IFN; IFN-κ. HERC6 knockdown in human keratinocytes results in enhanced induction of i...

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Bibliographic Details
Main Authors: Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Bioinformatics
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224002074

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http://www.sciencedirect.com/science/article/pii/S2589004224002074

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