COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients

COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients

Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII and Wnt signaling have recently been associated with adipogenic differentiation...

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Bibliographic Details
Main Authors: Flavia I.V. Errera, Luís H. Canani, Erika Yeh, Érika Kague, Lucia M. Armelin-Corrêa, Oscar T. Suzuki, Balduíno Tschiedel, Maria Elizabeth R. Silva, Andréa L. Sertié, Maria Rita Passos-Bueno
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-03-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
COL18A1
obesidade
adipogênese
endostatina
frizzled
obesity
adipogenesis
endostatin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100012

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