AI-powered discovery of a novel p53-Y220C reactivator

AI-powered discovery of a novel p53-Y220C reactivator

IntroductionThe p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression.MethodsIn this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that specifically restore the wild-type p53 conformation fr...

Full description

Bibliographic Details
Main Authors: Shan Zhou, Dafei Chai, Xu Wang, Praveen Neeli, Xinfang Yu, Aram Davtyan, Ken Young, Yong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
mutant p53
Y220C
artificial intelligence
small molecule inhibitors
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1229696/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1229696/full

Similar Items